Genetic hyperthyroidism: hyperthyroidism due to activating TSHR mutations

Familial hyperthyroidism due to mutations in TSH receptor

Reversible male subfertility due to hyperthyroidism.

A 26-year-old man with a one-year history of attempted conception was referred to a male subfertility clinic. Two previous semen analyses had disclosed oligospermia with sperm counts of 11 x 109/1 on both occasions (figure). He had had classical symptoms of thyrotoxicosis for five years and 18 months earlier had been investigated for palpitations. Examination showed a diffuse goitre, tremor, an...

Simultaneous induction of Graves’ hyperthyroidism and Graves’ ophthalmopathy by TSHR genetic immunization in BALB/c mice

BACKGROUND Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no id...

Hyperthyroidism.

The thyroid gland is located at the base of the neck, in front of the trachea (windpipe) and esophagus (tube that connects the mouth with the stomach). The thyroid produces thyroid hormone, which helps to regulate many body functions. In hyperthyroidism, the thyroid is overactive and produces more thyroid hormone than the body needs. Women are more likely than men to have hyperthyroidism, and i...

Hyperthyroidism

Hyperthyroidism is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormone. The most common cause of this syndrome is Graves' disease, followed by toxic multinodular goitre, and solitary hyperfunctioning nodules. Autoimmune postpartum and subacute thyroiditis, tumors that secrete thyrotropin, and drug-induced thyroid dysfunction, are also important...